GMC Domains
- THE DOCTOR AS A SCHOLAR
- TD 8: APPLICATION OF BIOMEDICAL SCIENTIFIC PRINCIPLES, METHOD AND KNOWLEDGE
- Medical knowledge: ANATOMY (TD 8.1)
- Medical knowledge: PHYSIOLOGY (TD 8.2)
- Medical knowledge: BIOCHEMISTRY (inc. Metabolism) (TD 8.3)
- Medical knowledge: CELL BIOLOGY (TD 8.4)
- Medical knowledge: MOLECULAR BIOLOGY and GENETICS (TD 8.5, 8.6)
- Medical knowledge: PATHOLOGY (TD 8.7)
- Medical knowledge: CANCER
- Medical knowledge: IMMUNOLOGY and INFLAMMATION (TD 8.8)
- Medical knowledge: MICROBIOLOGY and INFECTION (TD 8.9)
- Medical knowledge: PHARMACOLOGY (TD 8.10)
- Medical knowledge: NUTRITION (TD 8.11)
- Medical knowledge: CLINICAL FEATURES of DISEASE (TD 8 b)
- TD 9: APPLICATION OF PSYCHOLOGICAL PRINCIPLES, METHOD AND KNOWLEDGE
- TD 10: APPLICATION OF SOCIAL SCIENCE PRINCIPLES, METHOD AND KNOWLEDGE
- TD 11. PRINCIPLES, METHODS AND KNOWLEDGE OF POPULATION HEALTH
- TD 12; APPLICATION OF SCIENTIFIC METHOD AND APPROACHES TO MEDICAL RESEARCH
- TD 8: APPLICATION OF BIOMEDICAL SCIENTIFIC PRINCIPLES, METHOD AND KNOWLEDGE
- THE DOCTOR AS A PRACTITIONER
- TD 13: CARRY OUT A CONSULTATION WITH A PATIENT
- TD 14: DIAGNOSE AND MANAGE CLINICAL PRESENTATIONS
- Clinical skills: INTERPRETING FINDINGS AND INITIAL ASSESSMENT (TD 14 a-b)
- Clinical skills: PLANNING AND INTERPRETING INVESTIGATIONS (TD 14 c-d)
- Clinical skills: MAKING A DIAGNOSIS and CLINICAL JUDGEMENT (TD 14 e-f)
- Clinical skills: FORMULATING A TREATMENT PLAN (TD 14 g)
- Clinical skills: SURGERY and ANAESTHETICS (TD 14 g)
- Clinical skills: SUPPORTING PATIENTS and IDENTIFYING ABUSE and NEGLECT (TD 14 h-i)
- Clinical Skills: CARE OF PATIENTS AND RELATIVES AT END OF LIFE (TD 14 j)
- TD 15: COMMUNICATE EFFECTIVELY WITH PATIENTS AND COLLEAGUES
- TD 16: PROVIDE IMMEDIATE CARE IN MEDICAL EMERGENCIES
- TD 17: PRESCRIBE DRUGS SAFELY, EFFECTIVELY AND ECONOMICALLY
- TD 18: CARRY OUT PRACTICAL PROCEDURES SAFELY AND EFFECTIVELY
- TD 19: USE INFORMATION EFFECTIVELY IN A MEDICAL CONTEXT
- THE DOCTOR AS A PROFESSIONAL
- TD 20: BEHAVE ACCORDING TO ETHICAL AND LEGAL PRINCIPLES
- TD 21: REFLECT, LEARN AND TEACH OTHERS
- TD 22: LEARN AND WORK EFFECTIVELY WITHIN A MULT-PROFESSIONAL TEAM
- TD 23: PROTECT PATIENTS AND IMPROVE CARE
- Professional issues: DUTIES OF A DOCTOR (TD 23 a-b)
- Professional issues: MEDICAL FRAMEWORK IN THE UK (TD 23 c)
- Professional issues: RISK MANAGEMENT and PATIENT SAFETY (TD 23 d)
- Professional issues: GOVERNANCE, QUALITY MATTERS and AUDIT (TD 23 e)
- Professional issues: PERSONAL ATTITUDES and SELF CARE (TD 23 f-j)
TD 8: APPLICATION OF BIOMEDICAL SCIENTIFIC PRINCIPLES, METHOD AND KNOWLEDGE: Medical knowledge: MICROBIOLOGY and INFECTION (TD 8.9)
Index
- General Outcomes for Microbiology and Infection
- Microbiology of Cardiovascular Infections
- Microbiology of Respiratory Infections
- Microbiology of Haematological Infections
- Microbiology of Gastrointestinal Infections
- Microbiology of the Renal System and Urinary Tract
- Microbiology of Childhood Infections
- Microbiology of Sexually Transmitted Infections (Inc. HIV/AIDS)
- Microbiology of Obstetric and Gynaecological Infections
- Microbiology of Neurological Infections
- Microbiology of Musculoskeletal Infections
- General Outcomes for Microbiology and Infection
- General Outcomes for Microbiology
- Be able to distinguish between the different groups of pathogens (FM1)
- List the basic characteristics of viruses and the criteria by which they are classfied (FM1)
- Describe the structure of viruses, defining the terms: capsid; capsomeres; genome; nucleocapsid, envelope (FM1)
- Outline the structure of bacteria, emphasising differences from eukaryotic cells (FM1)
- Causative organisms leading to bone and joint sepsis (LOC2)
- Describe how bacteria can be classified on the basis of staining properties and morphology (FM1)
- Describe how viruses replicate (FM1)
- List those parts of the body which should be sterile and those which have a normal flora (FM1)
- Terminology used in Microbiology
- Pathogenesis
- Describe portals of entry of pathogens and their adherence mechanisms (FM1)
- Discuss major infectious disease problems; case studies of bacteria; lessons from history (public health, pathology, pathogenesis)
- Have basic knowledge of the epidemiology and pathogenesis of malaria and of the parasite life cycle
- For viruses, list their mechanisms of persistence, and explain their harmful effects (killing cells, alter functions of cells, giant cell formation, malignant change, hypersensitivity) (FM1)
- For bacteria, list their mechanisms of persistence, describe how they make you ill, and how they survive the host response (involving stress, stealth, scavenging, striking back) (FM1)
- Describe how pathogens are disseminated through host organs and how they exit from the host (FM1)
- Antimicrobials and Bacterial Infections
- Antimicrobial therapy (LOC2)
- List innate and acquired defences against infection in man. (CSP3)
- Describe the principle of selective toxicity (FM1)
- Define humoral and cellular immunity. (CSP3)
- Describe the structure and function of targets in microbes that differ from their counterparts in the host (FM1)
- List iatrogenic and non-iatrogenic causes of immunosuppression. (CSP3)
- List organisms causing disease in the immunocompromised host relating these to the immunological defect particularly associated with infection by a particular organism. (CSP3)
- Outline the clinical evaluation and diagnostic procedures used when investigating the febrile immunosuppressed patient. (CSP3)
- Understand the mechanisms and implications of inherent and acquired antimicrobial resistance in bacteria (FM1)
- List principles of therapy in the immunocompromised host. (CSP3)
- List preventive measures employed against infection in known immunosuppressed hosts. (CSP3)
- Antivirals and Viral Infections
- Know the concept of inhibition of virus specific enzymatic activities (FM1)
- Describe the nature of viruses and the main therapeutic interventions against viral disease.
- Innate and acquired defences against infections (CSP3)
- List the stages in the viral replication cycle from virus entry into the cell to virus release
- Define humoral and cellular immunity (CSP3)
- How to inhibit cellular factors important for virus replication (FM1)
- Iatrogenic and non-iatrogenic causes of immunosuppression (CSP3)
- Explain why emerging viruses are such a threat.
- What are the treatment strategies and treatment side effects for selected viral infections (FM1)
- List the drugs that can inhibit each stage of the viral life cycle
- Lists organism causing disease in the immunocompromised host (CSP3)
- List the stages of the influenza life cycle that can be inhibited by drugs and the drugs concerned
- Outline clinical evaluation and diagnostic procedures (CSP3)
- Principles of therapy in the immunocompromised host (CSP3)
- Retroviruses
- List the three sets of genes in retroviruses (Gag, Pol, Env), their order and what they encode (CSP3)
- Draw the retroviral life cycle, naming the enzymes involved (CSP3)
- List the retroviruses that cause disease in humans and the diseases they cause (CSP3)
- Account for HTLV1 causation of Adult T-cell Leukaemia and Myelopathy, including Tax gene; describe these conditions and their treatment (CSP3)
- Describe Human Endogenous Retroviruses (CSP3)
- Antifungals and Fungal Infections
- Protozoal Infections
- Sources of Infection and Routes of Transmission
- Define the terms: incidence; prevalence; endemic; epidemic; pandemic (FM1)
- To realise the concept of normal skin microflora and of chronic carriage of micro-organisms, such as Staphylococcal aureus. (LOC2)
- Discuss how pathogens are transmitted (FM1)
- Discuss methods of controlling infectious diseases (prevention, immunisation, treatment) and the significance of herd immunity. (FM1)
- List the major routes of transmission of HIV (I&I 4)
- Management of Infection
- Metabolic and Immunological Consequences of Infection
- Prevention and Control of Infection
- General Outcomes for Microbiology
- Microbiology of Cardiovascular Infections
- Endocarditis
- Learn about the organisms that cause infective endocarditis and explain how cardiac infection with each may be acquired (CR3)
- Be able to define minimum inhibitory concentration (MIC), minimal bactericidal concentration (MBC) and antimicrobial synergy (CR3)
- Be able to list the common bacterial causes of endocarditis in people with normal valves, abnormal native valves and prosthetic valves (CR3)
- Infective endocarditis: organisms, valves, guidelines for choosing antimicrobial (CSP3)
- Rheumatic Fever and Rheumatic Heart Disease
- Endocarditis
- Microbiology of Respiratory Infections
- General Outcomes for Respiratory Tract Infections
- Lower Respiratory Tract Infections - General
- Describe the main causes of lower respiratory tract infections.
- Explain how organisms causing lower respiratory tract infections are differentiated and identified by microbiological investigations (CR3)
- Discuss the importance of lower respiratory tract infections as a cause of morbidity and mortality, both in the hospital and community setting.
- Describe the clinical features (signs and symptoms) that suggest an atypical organism is responsible for lower respiratory tract infections
- Upper Respiratory Tract Infections - General
- Chronic Obstructive Pulmonary Disease (COPD)
- Pneumonia
- Cystic Fibrosis
- Tuberculosis
- Microbiology of Haematological Infections
- Microbiology of Gastrointestinal Infections
- Gastroenteritis and other Diarrhoeal Infections
- Significance of GI infections as a cause of morbidity /mortality
- Routes of transmission
- Major bacterial/protozoal /viral causes in the UK/worldwide
- Laboratory methods for diagnosis
- Public health measures to prevent them
- Abdominal infections and diarrhoea: prophylaxis and treatment of abdominal sepsis; management of infective diarrhoea (rehydration, isolation, notification, antimicrobials), clostridium difficile (CSP3)
- Hepatitis
- Helminthic Infections
- Gastroenteritis and other Diarrhoeal Infections
- Microbiology of the Renal System and Urinary Tract
- Urinary Tract Infections
- Classification, predisposing factors, symptoms, & diagnostic criteria for urinary tract infections.
- Types of samples, sources of error, & testing strategies.
- Causative organisms in urinary tract infections in general practice, in hospital, with calculi, & in the post-treatment patient.
- Treatment in UTIs: available antimicrobials, resistance to antimicrobials, treatment strategies & regimes, to treat or not to treat.
- UTIs in special groups; infants/children, pregnant women, nonpregnant women, young men, diabetic patients, people with underlying renal abnormalities, the elderly.
- Prevention & treatment of UTIs by non-antibiotic methods: fluid intake, cotton underwear, avoid bubble baths, & cranberry juice.
- Urinary Tract Infections
- Microbiology of Childhood Infections
- Microbiology of Sexually Transmitted Infections (Inc. HIV/AIDS)
- General Outcomes for HIV and AIDS
- Recognise the significance and list possible causes for the following symptoms in an HIV infected person: Generalised seizures, loss of vision, focal neurological deficit, change in affect, shortness of breath, rash
- Describe factors affecting rates of transmission following exposure to HIV-infected materials (I&I 4)
- Understand the pathogenesis, diagnosis and management of HIV infection (I&I 4)
- To describe available Post Exposure Prophylaxis regimens for HIV and how best to access these regimens
- To manage under supervision or refer as appropriate the presentations of HIV positive patients with Pneumocystis pneumonia, Candidiasis, Toxoplasmosis, Cryptococcosis, Tuberculosis, Cytomegalovirus, Kaposi’s Sarcoma, Lymphoma, Hepatitis B and C
- Recognise the clinical presentations of primary HIV infection (seroconversion)\and describe the management of a suspected case (I&I 4)
- To be able to explain pathogenesis of HIV
- List the opportunistic infections that commonly cause clinical disease in HIV infection
- Describe the spectrum of clinical problems associated with HIV infection: primary HIV infection, asymptomatic HIV infection, persistent generalised lymphadenopathy, symptomatic HIV infection and Acquired Immunodeficiency Syndrome (I&I 4)
- To recognise the presentations of HIV infected patients with Pneumocystis pneumonia, Candidiasis, Toxoplasmosis, Cryptococcosis, Tuberculosis, Cytomegalovirus, Kaposiís Sarcoma, Lymphoma, Hepatitis B and C
- Understand the pathogenesis, diagnosis, management and prevention of the following in the context of HIV: Pneumocystis jiroveci, Cryptococcus neoformans, Candidia albicans, Toxoplasma gondii, Cryptosporidium parvum, Mycobacterium tuberculosis, atypical My (I&I 4)
- Describe the structure of HIV and name the important constituent structures (I&I 4)
- Demonstrate knowledge of the CDC classification system for HIV infection (I&I 4)
- List the phases of the HIV replication cycle that can be inhibited by drug treatment
- Explain the functions of the various parts of the HIV virus particle (I&I 4)
- Describe the genome of HIV with reference to the regulatory proteins produced and their functions. (I&I 4)
- Demonstrate the life cycle of HIV, with particular reference to the areas that have implications for therapeutic interventions (I&I 4)
- Describe how widespread HIV is; know what is meant by clades (CSP3)
- Demonstrate the events that occur at a cellular level during acute HIV infection (I&I 4)
- Sexually Transmitted Infections - General
- Understand the pathogenesis, diagnosis and management of Human Papilloma Virus, Molluscum contagiosum and Sarcoptes scabiei (I&I 4)
- Understand the pathogenesis, diagnosis and management of Herpes Simplex Virus, Syphilis, Lymphogranuloma Venereum, (I&I 4)
- Understand the pathogenesis, diagnosis and management of Chlamydia trachomatis, Neisseria gonorrhoeae, Candida albicans, Trichomonas Vaginalis, Bacterial Vaginosis and Non-Specific Urethritis (I&I 4)
- List the major routes of transmission of HIV (I&I 4)
- General Outcomes for HIV and AIDS
- Microbiology of Obstetric and Gynaecological Infections
- Microbiology of Neurological Infections
- Microbiology of Musculoskeletal Infections