Specialties
- WHOLE PERSON
- CARDIORESPIRATORY
- METABOLISM
- HUMAN DEVELOPMENT
- BRAIN AND BEHAVIOUR
- LOCOMOTOR
METABOLISM: Gastrointestinal System
Index
- General Outcomes for Gastrointestinal System
- Acute Abdomen
- Diverticular Disease
- Disorders of the Hepato-biliary System
- Nutrition and Malnutrition
- GI Ulcer Disease and Bleeding
- Herniae
- Obstructive Disorders of the GI System
- Trauma to the GI System
- Aneurysms
- Gastrointestinal Cancer
- Diarrhoeal and Inflammatory Disorders
- Vascular Conditions
- GI Surgery and Anaesthetics (General)
- Malabsorption Disorders
- General Outcomes for Gastrointestinal System
- Medical knowledge: ANATOMY (TD 8.1)
- Peritoneum
- Describe the location and function of the visceral and parietal peritoneum
- Outline the embryology of the foregut, the midgut and the hindgut and the formation of the peritoneal cavity
- Describe the general arrangements of the gastrointestinal tract and associated viscera
- Describe the difference between retroperitoneal organs and intraperitoneal organs
- Understand the extent and the sub-divisions of the peritoneal cavity
- Surface Anatomy of the Abdomen
- Abdominal / Gut Anatomy - General
- The anatomical basis of the abdominal examination
- Outline the basic components that make up the wall of the alimentary tract. (GEP/DGM)
- Know the surgical anatomy of the abdomen including the peritoneum (MET3A)
- Define hernia and list the most common hernias
- Define the acronyms MALT and GALT. (GEP/DGM)
- Explain the terms intraperitoneal and retroperitoneal
- Describe variations in the basic wall plan at particular sites (i.e. junctions, retroperitoneal regions). (GEP/DGM)
- Describe the changing nature and function of the mucosae in the alimentary tract. (GEP/DGM)
- Explain how the mucosa of the small intestine is adapted to increase its surface area for absorption. (GEP/DGM)
- Outline the cellular composition of the epithelia in each part of the alimentary tract. (GEP/DGM)
- Know the anatomy and blood supply to the stomach and duodenum and their relation to the pancreas (MET3A)
- The Abdominal Wall
- Circulation of the Abdomen
- Peritoneum
- Medical knowledge: PHYSIOLOGY (TD 8.2)
- Gastrointestinal Physiology - General
- Critical role of the intestine in animal/human evolution (GEP/DGM, MET1)
- Normal gastrointestinal tract (GEP/DGM)
- Diseases of oesophagus - Reflux and cancer
- Diseases of stomach - acid secretion; cancer and bleeding
- Small intestine - absorption; immune system, coeliac disease and inflammatory bowel disease (GEP/DGM)
- Summary - reasons for gastroenterology being an interesting and important area in which to work (GEP/DGM)
- Gastrointestinal Motility
- Describe the control of the lower oesophageal sphincter
- Know the normal function of the large bowel (MET3A)
- Know the volumes of fluid secreted in the GI tract
- Describe the process of gastric emptying
- Understand the process of fluid losses and replacement in bowel obstruction
- Describe the mechanisms and causes of vomiting
- State approximate gastrointestinal transit times
- Describe the propulsive and non-propulsive movements of the small and large intestines
- Describe the process of defaecation
- Define constipation and diarrhoea and list causes of each condition
- Digestion and Absorption
- Compare and contrast the fate of absorbed fat with that of endogenous fat during the post-absorptive phase
- Outline the route taken by chylomicra from intestinal mucosa cells to the liver and describe the overall changes in their lipid content during their journey
- Distinguish between portal and lymphatic routes of nutrient transport
- Describe the synthesis and transport of triacylglycerol from the liver to the periphery as very low density lipo-protein (VLDL)
- Describe the roles of the salivary glands, stomach, liver, pancreas and small intestine in the digestion of carbohydrates, lipids and proteins
- Describe the main characteristics of the transport systems for amino acids and monosaccharides
- Draw a diagram summarising the transformation of very low density lipo-protein (VLDL) to low density lipo-protein (LDL) showing the subsequent fates of the latter
- Explain how digested lipids are absorbed by the intestinal epithelium. Describe how the lipids are further metabolised and incorporated into chylomicra
- Outline the role of lipoprotein lipase in the hydrolysis of lipoprotein triacylglycerol
- Explain how low density lipoprotein (LDL) particles are taken up by cells
- Pancreas
- Gastrointestinal Physiology - General
- Medical knowledge: BIOCHEMISTRY (inc. Metabolism) (TD 8.3)
- Glucose and Glycogen Metabolism
- Outline the mechanisms of glucose uptake into cells
- Outline the role of liver glycogen as a source of blood glucose during a normal feeding cycle. (GEP/DGM)
- Define gluconeogenesis and state the tissues in which gluconeogenesis occurs.
- List the major metabolic actions of insulin on glucose and lipid metabolism in the postprandial state
- Outline the potential metabolic fates of glucose 6-phosphate
- Outline the advantages of glycogen as a storage molecule.
- State the circumstances under which gluconeogenesis will occur.
- Distinguish between the facilative glucose transporters (GLUT's) with respect to tissue distribution and kinetic characteristics
- Describe how fatty acid oxidation facilitates gluconeogenesis.
- Describe the structure of glycogen. (GEP/DGM)
- List the major precursors used for gluconeogenesis, and identify their tissues of origin.
- Understand the significance of the regulatory and kinetic characteristics of glucokinase and hexokinase with respect to their tissue locations and physiological roles.
- Note enzymes in the gluconeogenic pathway that by-pass irreversible steps in glycolysis (glucose 6-phosphatase, fructose 1,6-bisphosphatase, phosphoenolpyruvate (PEP) carboxykinase, pyruvate carboxylase).
- Outline the overall pathway of glycogen synthesis and degradation.
- Phosphofructokinase is the major control point of glycolysis. Specify how it responds to cellular messages.
- Outline the circumstances under which glycogen synthesis and degradation will occur. (GEP/DGM)
- Outline the hormonal regulation of gluconeogenesis.
- Understand that glycolysis can produce ATP by substrate level phosphorylation.
- Understand that the key enzymes glycogen synthase and glycogen phosphorylase are controlled both by reversible phosphorylation.and by metabolite effectors
- Understand the different roles of glycogen storage in muscle and liver. Be aware of the differences in the fate of the glucose 1-phosphate that results from glycogenolysis in muscle and liver.
- Lactose (milk sugar) is an important source of galactose. Understand how galactose is metabolized and the cause and consequences of galactosaemia.
- Understand the different roles of glycogen storage in muscle and liver.
- Fat Metabolism
- Discuss briefly the significance of lipid as a source of metabolic energy in the human body.
- List the major metabolic actions of insulin on glucose and lipid metabolism in the postprandial state
- Compare and contrast the biosynthesis and the breakdown of triacylglycerols (triglycerides).
- Discuss briefly the hormonal control of triacylglycerol in metabolism.
- Describe how fatty acids are delivered from adipose tissue to the mitochondria of cells in other organs.
- Describe how fatty acids are degraded by b-oxidation in mitochondria.
- Describe in outline how cholesterol is synthesised and metabolised.
- Metabolism - General
- Define inherited metabolic disorders and list common inherited metabolic disorders. (GEP/DGM)
- Discuss the links between metabolism and nutrition
- Outline the metabolic impact of Von Gierke's disease. (GEP/DGM)
- Explain the significance of linkage between the important metabolic pathways, and their apparent complexity
- Outline the biochemical basis and consequences of galactosaemia. (GEP/DGM)
- Describe with examples, the coordination of metabolism between the organs and between subcellular compartments
- Discuss the mechanisms for and the importance of the control of metabolism
- Outline the biochemical basis and consequences of McArdle's disease (GEP/DGM)
- Describe the consequences of a deficiency of liver fructokinase or fructose 1-phosphate aldolase. (GEP/DGM)
- Outline the inherited metabolic disorders of amino acid metabolism (GEP/DGM)
- Describe the consequences of phenylketonuria. (GEP/DGM)
- List the genetic causes of dyslipidaemia. (GEP/DGM)
- Describe the consequences of familial hypercholesterolaemia. (GEP/DGM)
- Energy from Metabolism
- Define basal metabolic rate and total energy expenditure and indicate how they can be (a) measured (b) estimated.
- Outline the characteristics of muscle slow twitch (type 1) and fast twitch (type 2) fibres.
- Describe how, after digestion, the simple molecules of food are largely broken down to a final common aerobic pathway of energy metabolism in which an acetate group is oxidised in order to power ATP production (Krebs cycle and oxidative phosphorylation)
- Compare the metabolic pathways employed during sprinting, middle-distance running and marathons.
- Describe the regulatory role of AMP-activated protein kinase (AMPK) in exercise.
- Distinguish between the two peripheral types of muscle fibre indicating how white fibres favour anaerobic metabolism and red fibres aerobic, endurance related exercise.
- Describe how AMP affects glucose handling by skeletal muscle.
- Discuss the relative energy expenditure during some common daily forms of exercise.
- Explain why the oxidation of pyruvate is a key step in human metabolism.
- Understand the mechanism whereby AMPK lowers malonyl-CoA concentrations and allows increased fat oxidation.
- Describe the metabolic organisation and role of the Krebs cycle.
- Outline the metabolic adaptations occurring during fatigue.
- Explain how co-enzymes link oxidative metabolism and ATP synthesis.
- Nitrogen Metabolism
- Understand the difference between glucogenic and ketogenic amino acids.
- Appreciate the general metabolism of the carbon skeletons and amino groups from amino acids and how this interfaces with carbohydrate and lipid metabolism.
- Understand the function of alanine and glutamine in interorgan carbon and nitrogen flow.
- Outline how amino groups are funnelled into the urea cycle. Understand why urea is a better excretion product than ammonia.
- Fatty Acids
- Describe the control of fatty acid synthesis via regulation of acetyl-CoA carboxylase.
- Understand the purpose of triglyceride mobilisation (lipolysis).
- State the products of lipolysis and contrast the metabolic fates of the glycerol and fatty acid moieties in triglyceride.
- Understand how the activity of hormone-sensitive (triglyceride) lipase is regulated.
- Outline the overall pathway of fatty acid activation and transport into the mitochondrial matrix via the carnitine shuttle.
- Be aware of the regulatory importance of malonyl-CoA for regulation of mitochondrial long-chain fatty acid oxidation at the level of carnitine palmitoyl transferase I.
- Outline the general features of the beta-oxidation spiral and understand the role of beta-oxidation in ATP production.
- State the site and mechanism of ketone body production (ketogenesis).
- Specify the fate of ketone bodies in tissues such as the muscle and brain.
- Describe the effects of excessive ketone body production.
- Amino Acids
- Urea Cycle
- Nitrogen Balance
- Glucose and Glycogen Metabolism
- Medical knowledge: PATHOLOGY (TD 8.7)
- Gastrointestinal System - General Pathology
- Outline the changing nature and function of the epithelial lining of the alimentary tract. (GEP/DGM)
- Describe the characteristic features of the gastric mucosa.
- Draw a diagram of the normal small intestinal mucosa and show what changes occur in enteropathy. (GEP/DGM)
- Illustrate the structure of the upper small intestinal wall (serosa to mucosa). (GEP/DGM)
- Describe common pathologies of the gastrointestinal tract. (GEP/DGM)
- Gastrointestinal System - General Pathology
- Medical knowledge: IMMUNOLOGY and INFLAMMATION (TD 8.8)
- Immunology - General Outcomes
- Appreciate that the gut is a highly vulnerable tissue, susceptible to infections.
- Realise that only a single layer of epithelium separates the gut lumen from the tissues.
- Appreciate that the gut contains the majority of the immune system in the body
- IgA is the secretory immunoglobulin
- While the gut epithelium is absorbing nutrients, it is also transporting large amounts of IgA into the gut lumen
- Absence of T cells in the gut leads to chronic low grade infections
- That mucosal protective immune responses are generated in Peyer's patches and expressed in lamina propria
- Immunology - General Outcomes
- Medical knowledge: NUTRITION (TD 8.11)
- Under nutrition and Malnutrition
- Obesity
- General Outcomes for Nutrition
- Artificial Feeding (inc. Enteral Nutrition & Total Parenteral Nutrition)
- Describe how feeds can be administered: sip feeds; nasogastric and gastrostomy (MET3A)
- Explain how artificial feeding techniques minimise the principal complications of aspiration, dehydration, hyperglycaemia, sodium overload and diarrhoea (MET3A)
- Describe the techniques of peripheral and central venous parenteral nutrition and how the technique employed may reduce the risk of thrombophlebitis, sepsis, hyperglycaemia and sodium overload (MET3A)
- Protein Energy Malnutrition (PEM)
- Eating Disorders
- Medical knowledge: CLINICAL FEATURES of DISEASE (TD 8 b)
- General Outcomes for Gastrointestinal Disease
- How to identify the common clinical signs that signal a patient with abdominal disease is unwell
- How to systematically observe a patient from the end of the bed using the 'feet to face' principle, identifying some common abnormalities of abdominal disease
- Enumerate the clinical signs which are relevant to the aetiology or complications of obesity
- How to perform a systematic examination of a patient with abdominal disease including some peripheral and central clinical signs
- General Outcomes for Gastrointestinal Disease
- Clinical skills: HISTORY (TD 13 a-b)
- Abdominal Examination
- The anatomical basis of the abdominal examination
- How to gain consent to examine a person/patient's abdomen
- Appreciate the examination techniques required to perform superficial and deep palpation of the abdomen (MET1)
- How to position a patient/person correctly prior to examining their abdomen
- Appreciate the examination techniques required to assess a patient for hepatomegaly and splenomegaly (MET1)
- How to identify the common clinical signs that signal a patient with abdominal disease is unwell
- Appreciate the examination technique of balloting (for renal enlargement). (MET1)
- How to systematically observe a patient from the end of the bed using the 'feet to face' principle, identifying some common abnormalities of abdominal disease
- Appreciate how to auscultate for bowel sounds. (MET1)
- Demonstrate the appropriate techniques required to perform a holistic clinical examination of a patient with abdominal disease
- How to perform a systematic examination of a patient with abdominal disease including some peripheral and central clinical signs
- The associated clinical examination and investigations required to complete a clinical assessment of a patient with abdominal disease
- Know what a patient with peritonitis board like rigidity is like to examine (MET3A)
- Patient History for GI Disorders
- Taking a History
- Abdominal Examination
- Clinical skills: PLANNING AND INTERPRETING INVESTIGATIONS (TD 14 c-d)
- Clinical skills: MAKING A DIAGNOSIS and CLINICAL JUDGEMENT (TD 14 e-f)
- General Outcomes for Gastrointestinal Diagnosis
- How to identify the common clinical signs that signal a patient with abdominal disease is unwell
- How to systematically observe a patient from the end of the bed using the 'feet to face' principle, identifying some common abnormalities of abdominal disease
- How to perform a systematic examination of a patient with abdominal disease including some peripheral and central clinical signs
- Know when and how to investigate a patient with diarrhoea, constipation or altered bowel habit (MET3A)
- General Outcomes for Gastrointestinal Diagnosis
- Clinical skills: PRESCRIBING DRUGS SAFELY AND EFFECTIVELY (TD 17 a-h)
- Pharmacological Therapy - Gastrointestinal Disorders (General)
- Professional issues: WORKING IN TEAMS (TD 22 a-c)
- Multi-disciplinary Team Work (MDT)
- Medical knowledge: ANATOMY (TD 8.1)
- Acute Abdomen
- General Outcomes for Acute Abdomen
- Recognise the presentation of a patient with an acute abdomen (MET3A)
- Be able to take a history of a patient with an acute abdomen (MET3A)
- Be able to perform an examination of a patient with an acute abdomen (MET3A)
- Be able to elicit guarding (voluntary and involuntary), and rebound tenderness (MET3A)
- Able to offer a suitable differential diagnosis (MET3A)
- Be able to classify the causes of an acute abdomen (MET3A)
- Be able to institute a management plan for a patient with an acute abdomen (MET3A)
- Know the indications for referral from primary care (MET3A)
- Appendicitis
- Know the anatomy of the appendix.
- Know the different positions of the appendix (retrocaecal, post-ileal, pre-ileal, pelvic) (MET3A)
- Describe the surgical anatomy of appendicectomy (MET3A)
- Know the classical and alternative presentations of appendicitis (MET3A)
- Know the different clinical picture of acute and perforated appendicitis (MET3A)
- Know the role of imaging in the diagnosis of appendicitis (MET3A)
- Know the differential diagnosis of appendicitis (MET3A)
- Be able to discriminate appendicitis from the other differential diagnoses on the patient's history (MET3A)
- Describe the blood and urine results in appendicitis (MET3A)
- Know the management of an appendix mass (MET3A)
- Know the role laparoscopy in the diagnosis and treatment of appendicitis (MET3A)
- Know the different surgical approaches to appendicectomy (MET3A)
- Know the complications of appendicectomy (MET3A)
- Know the aetiology of appendicitis (MET3A)
- Peritonitis
- Pancreatitis
- Understand the difference between mild and severe pancreatitis (MET3A)
- Understand the difference between mild and severe pancreatitis
- Be able to describe the early and late complications of acute pancreatitis (MET3A)
- Be able to describe the early and late complications of acute pancreatitis
- Understand the difference between acute and chronic pancreatitis (MET3A)
- Understand the difference between acute and chronic pancreatitis
- Know the classical clinical presentation of acute pancreatitis (MET3A)
- Know the classical clinical presentation of acute pancreatitis
- Know the causes of acute pancreatitis
- Know the causes of acute pancreatitis (MET3A)
- Know the pathophysiology of acute pancreatitis (MET3A)
- Know the pathophysiology of acute pancreatitis
- Know the differential diagnosis of acute pancreatitis (MET3A)
- Know the differential diagnosis of acute pancreatitis
- Know the diagnostic investigations useful for the diagnosis of acute pancreatitis (MET3A)
- Know the diagnostic investigations useful for the diagnosis of acute pancreatitis
- Know the role of Ultrasound, CT and ERCP in the management of acute pancreatitis (MET3A)
- Know the role of Ultrasound, CT and ERCP in the management of acute pancreatitis
- Know Atlanta criteria for severity scoring (MET3A)
- Know the Atlanta criteria for severity scoring
- Know the importance and prognostic value of the scoring systems (Ranson & Glasgow) in patient management (MET3A)
- Know the importance and prognostic value of the scoring systems (Ranson & Glasgow) in patient management
- Know the current indication for antibiotics in acute pancreatitis (MET3A)
- Know the current indication for antibiotics in acute pancreatitis
- Be aware that acute severe pancreatitis can lead to multi-organ failure (MET3A)
- Be aware that acute severe pancreatitis can lead to multi-organ failure
- Describe the principles of management of acute pancreatitis (MET3A)
- Describe the principles of management of acute pancreatitis
- Be aware of the role of surgery in the management of acute pancreatitis (MET3A)
- Be aware of the role of surgery in the management of acute pancreatitis
- Be able to describe the epidemiology of pancreatitis (MET3A)
- Be able to describe the aetiology of pancreatitis
- General Outcomes for Acute Abdomen
- Diverticular Disease
- General Outcomes for Diverticular Disease
- Understand the causes of diverticular disease (MET3A)
- Understand the complications of diverticular disease (MET3A)
- Know the common presentation of a patient with acute diverticulitis (MET3A)
- Know the medical management of a patient with acute diverticulitis (MET3A)
- Understand the role of surgery in the management of a patient with acute diverticulitis (MET3A)
- Colonic Diverticulae
- General Outcomes for Diverticular Disease
- Disorders of the Hepato-biliary System
- Hepato-biliary Disorders - General
- Be able to assess a patient with chronic liver disease
- Apply BRAINS&AIMS when choosing, giving and monitoring the following medications: Lactulose; Furosemide; Vasopressin; Phosphate Enema; Vitamin K; Spironolactone; Propranolol; Antibiotics eg Ciprofloxacin; Human Albumin Solution (MET3A)
- Give an overview of the role of the liver in carbohydrate, lipid and protein metabolism (GEP/DGM)
- Describe the role of the liver in glucose homeostasis (GEP/DGM)
- Be able to list the possible causes of acute/chronic liver disease.
- Understand the aetiopathology of the more common causes of acute/chronic liver disease
- Describe how the liver acts as an organ of detoxification (GEP/DGM)
- Discuss the role of the liver in protein synthesis (GEP/DGM)
- Be able to understand and interpret the blood tests required to establish a diagnosis
- Be able to understand the appropriate radiological investigations required when diagnosis acute/chronic liver disease
- Describe the storage functions of the liver (GEP/DGM)
- Describe the components of the biliary tree (including the sphincter of Oddi) (GEP/DGM)
- Be able to distinguish between the following terms and conditions: cirrhosis; alcoholic liver disease; encephalopathy; hepatitis; oesophageal varices; ascites
- Outline the formation and functions of bile (GEP/DGM)
- Know the management of ascites in a patient with chronic liver disease
- Describe the function of the gallbladder and its control (GEP/DGM)
- Give an account of the viral hepatides; describe the epidemiology, clinical features, pathology and complications
- Describe the enterhepatic circulation of bile (GEP/DGM)
- Describe the origin, metabolism and excretion of bilirubin (GEP/DGM)
- Outline the main causes of chronic hepatitis and briefly describe the pathology
- Be able to identify patients who are prone to drug-induced liver disease (MET3A)
- Be able to identify patients with active drug-induced hepatoxicity (MET3A)
- Be aware of the specialist drugs Interferon-a and Ribavirin. Be aware of their important adverse effects and drug-drug interactions (MET3A)
- Be aware that there are treatment options in hepatitis C infection (MET3A)
- Know how to monitor drug effects in patients with liver disease (MET3A)
- Know how to monitor patients for hepatotoxic drug effects (MET3A)
- Know which drugs may damage the liver and how this occurs (MET3A)
- Know the main indications / contraindications and mechanisms of action of and describe the main adverse effects of vasopressin (MET3A)
- Understand how liver disease alters how drugs work; adjust prescriptions in patients with liver disease (MET3A)
- Acute Hepatitis
- Viral hepatitis
- Cirrhosis (General)
- Alcohol Related Liver Disease
- Hepatic Failure
- Portal Hypertension
- Cholecystitis
- Know the pathology of gallstones (MET3A)
- Know the causes of cholecystitis (MET3A)
- Be able to differentiate between acute and chronic cholecystitis (MET3A)
- Be able to differentiate biliary colic from cholecystitis (MET3A)
- Be able to construct a differential diagnosis (MET3A)
- Be able to elicit Murphys sign (MET3A)
- Know the surgical options for the treatment of gallstones (MET3A)
- Know the epidemiology and risk factors for Gallstones (MET3A)
- Know the complications of cholecystitis (MET3A)
- Know the clinical signs and symptoms of acute cholecystitis (MET3A)
- Be able to take an accurate and comprehensive history from an acute patient with cholecystitis (MET3A)
- Competently be able to perform an abdominal examination for an acute patient with cholecystitis (MET3A)
- Be able to present clinical findings in a clear and logical manner (MET3A)
- Be able to describe radiological tests and findings to confirm diagnosis (MET3A)
- Be able to institute a management plan for a patient with acute cholecystitis (MET3A)
- Hepato-biliary Disorders - General
- Nutrition and Malnutrition
- General Outcomes for Nutrition and Malnutrition
- Recall the thermogenic effects of physical activity and food
- Outline the role of uncoupling proteins
- Define basal (resting) metabolic rate (BMR)
- Define energy balance and state how energy requirements are calculated
- List the main energy sources present in food
- Discuss the role of vitamins (and trace elements) as antioxidants (MET2)
- Give examples of water-soluble vitamins and list the principal function common to B vitamins (MET2)
- Describe the clinical syndromes associated with deficiencies of the water-soluble vitamins B1 (thiamin), B6, B12 and folate (MET2)
- List the treatment options for obesity
- Describe the different methods of nutritional assessment (GEP/DGM)
- Describe the prevalence of obesity in the UK and its relationship with the populations' intake of fat and carbohydrate and trends in physical exercise
- Give examples of important trace elements present in the diet within the context of clinical features of their deficiencies (MET2)
- Fasting and Starvation
- Understand possible adverse consequences of rapid refeeding after malnutrition
- Recall the salient features of anorexia and bulimia
- Outline the prevalence and significance of protein-energy malnutrition
- Outline the impact of common micronutrient deficiencies on health
- Outline the long-term effects of fasting and malnutrition on body composition and metabolism
- Define wasting and stunting
- Describe how to identify those at risk of malnutrition (GEP/DGM)
- Anorexia
- General Outcomes for Nutrition and Malnutrition
- GI Ulcer Disease and Bleeding
- General
- Define peptic ulceration; list the sites where peptic ulcers can occur (MET3A)
- Describe the most common cause of peptic ulcer and how this cause is eradicated
- Define peptic ulcer and describe the symptoms of ulceration
- Describe the different types of peptic ulcer and the underlying aetiological factors (MET3A)
- Describe the pathology of peptic ulcers; outline the features that distinguish between peptic ulcers and ulcerating carinomas (MET3A)
- Name an important group of ulceragenic (ulcer causing) drugs. Comment on a possible mechanism which may underline this effect
- Describe the treatment options for the management of peptic ulceration and non-ulcer dyspepsia (MET3A)
- Explain the mechanism of action of a named proton pump inhibitor used in the treatment of ulceration
- Know how to detect and eradicate H.pylori (MET3A, MET3A)
- Describe the treatment options for uncomplicated duodenal ulceration (MET3A)
- Outline the use of H2 blocking drugs in the treatment of gastric ulceration
- Discuss the management of recurrent peptic ulceration (MET3A)
- Know how to manage a patient with complicated peptic ulceration (MET3A)
- Discuss the value of endoscopy and barium examinations in the evaluation of patients with peptic ulcer disease (MET3A)
- Know how to manage a patient with dyspepsia in line with current NICE guidelines (MET3A)
- List the complications of peptic ulceration (MET3A)
- List the diagnostic features in a history which are suggestive of peptic ulceration (MET3A)
- Outline the causes of peptic ulceration; describe the role of H.pylori and non-steroidal anti-inflammatory drugs in the pathogenesis of peptic ulcers (MET3A)
- Be able to recognise the presence of free intra-peritoneal air on plain radiograph and CT Scan (MET3A)
- Be able to describe the epidemiology of duodenal and gastric ulceration (MET3A)
- Know the common anatomical sites of duodenal ulcer perforation (MET3A)
- Know the classical presentation of a patient with a perforated peptic ulcer (MET3A)
- Know the initial resuscitative measures in a patient with a perforated peptic ulcer (MET3A)
- Know the common causes of peptic ulcer perforation (MET3A)
- Understand the variable clinical presentations of a patient with a perforated peptic ulcer (MET3A)
- Know the available diagnostic investigations in a patient with perforated peptic ulcer (MET3A)
- Know the surgical management of a perforated peptic ulcer (MET3A)
- Know the conservative management of a perforated peptic ulcer and its indications (MET3A)
- Heatburn
- Gastro-oesophageal Reflux Disease (GORD)
- Describe the causes, pathology and complications of gastro-oesophageal reflux disease (GORD) (MET3A)
- Apply BRAINS&AIMS when choosing, giving and monitoring: Antacids; H2 receptor blockers eg Ranitidine; Proton Pump Inhibitors eg Omeprazole; Misoprostol; Bismuth Chelate; Metoclopramide; Vasopressin: IV Fluids/Blood (MET3A)
- Apply BRAINS&AIMS when choosing, giving and monitoring Antibiotics for H.Pylori eradication eg amoxycillin, clarithromycin, metronidazole; (MET3A)
- Understand the term Gastro-oesophageal Reflux Disease (GORD)
- Define Barrett's Oesophagus; outline the aetiology, pathogenesis. pathology and complications (MET3A)
- Be able to look up the main indications, contraindications, cautions, mechanisms of action, main adverse effects, interactions and dosage regimen of Bismuth Chelate and Vasopressin (MET3A)
- Be able to distinguish between the following terms and conditions: Upper / Lower GI Bleeding; Dyspepsia; Gastro-oesophageal Reflux Disease; Peptic / Gastric / Duodenal Ulceration (MET3A)
- Be able to discuss non-pharmacological therapy with a patient with GORD or Peptic Ulcer Disease (MET3A)
- Describe the therapeutic treatment of gastro-oesophageal reflux disease (GORD)
- Gastrointestinal Bleeding
- Be able to assess whether the patient requires immediate resuscitation (ABC) (MET3A)
- Be able to distinguish between upper and lower gastrointestinal bleeding (MET3A)
- Be able to list the causes of upper and lower gastrointestinal bleeding (MET3A)
- Be able to list the methods of fluid resuscitation (MET3A)
- Be able to outline the risk stratification of patients with a high risk of re-bleeding (MET3A)
- Know and understand the complications of massive blood transfusion (MET3A)
- Know how to manage a patient with an acute GI bleed (MET3A)
- Know the aetiopathology of the common causes of lower GI bleeding including: haemorrhoids; diverticular disease; ischaemic colitis; colonic polyps and carcinoma; angiodysplasia; ulcerative colitis (MET3A)
- Know the aetiology of common causes of upper GI bleeding including: duodenal ulcer; gastric ulcer; gastric erosions; oesophageal varices; Mallory Weiss tear (MET3A)
- Know the anatomy of the coeliac, superior and inferior mesenteric artery territories (MET3A)
- Know the endoscopic management of bleeding from the gastrointestinal tract (MET3A)
- Know the initial management of gastrointestinal haemorrhage (MET3A)
- Know the radiological investigations available for assessment of a gastrointestinal bleed (MET3A)
- Know the risk factors for upper gastrointestinal bleeding and the role of the GP in its prevention (MET3A)
- Know the role and indication of surgery in the management of gastrointestinal bleeding (MET3A)
- Know the role of red cell scanning and interventional radiology in the management of gastrointestinal bleeding (MET3A)
- Understand the role of oesophago-gastro-duodenoscopy (OGD) and colonoscopy in the management of gastrointestinal bleeding (MET3A)
- General
- Herniae
- General Outcomes for Hernia
- Know the pathogenesis of femoral hernias
- Discuss the formation of inguinal hernias, the relevant anatomy and the possible surgical interventions (GEP/HD, HD2)
- Know the causes and associated aetiological factors of femoral hernias
- Be able to define the term hernia
- Understand the following descriptive terms used to describe hernias: reducible; irreducible; incarcerated; strangulated; sliding
- Know and be able to describe the different types of hernia: inguinal; femoral; umbilical; paraumbilical; epigastric; incisional; parastomal
- Know the difference between direct, indirect and pantaloon inguinal hernias.
- Broadly understand the causes and associated aetiological factors of the other hernias
- Be able to take an appropriate history of a patient presenting with a lump in the groin
- Be able to perform an appropriate examination eliciting signs that would support the diagnosis of a direct inguinal, an indirect inguinal or femoral hernia
- Understand that the diagnosis of a hernia is primarily clinical but certain investigations are available to help delineate the diagnosis
- Know the management plan for a patient presenting with direct and indirect herniae; a femoral hernia; a strangulated hernia and a lump in the groin
- Know and be able to describe the principles and indications of the various surgical options for the repair of the following hernias: inguinal; femoral; strangulated
- Know the princples, indications, contra-indications and complications of the NON-operative management of the following hernias: inguinal; umbilical; epigastric
- Know the differential diagnosis for a lump in the groin
- Know the embryological development and the associated surgical anatomy of the inguinal and femoral canals
- Know and be able to describe the clinical features and presentation of: direct and indirect inguinal hernias; femoral hernias; strangulated hernias
- Know which hernias should be repaired surgically
- Know the pathogenesis of direct and indirect inguinal hernias
- Understand that a strangulated hernia can lead to ischaemia, perforation and sepsis
- Understand the principles of and the use of fluids, nasogastric intubation, antibiotics and urinary catheterisation in the stabilisation and monitoring of patients presenting with strangulated hernias
- Know that a strangulated hernia is a surgical emergency
- General Outcomes for Hernia
- Obstructive Disorders of the GI System
- Obstructive Jaundice
- Understand the physiology of the anatomy of the liver and gallbladder (MET3A)
- To be able to describe the physiology of bilirubin metabolism (MET3A)
- Understand the differences between conjugated and un-conjugated bilirubinaemia (MET3A)
- Be able to list the causes of jaundice (MET3A)
- Know the presentation of a patient with obstructive jaundice (MET3A)
- To be able to take a focussed history form a patient with obstructive jaundice (MET3A)
- Be able to present clinical findings with a patient with obstructive jaundice (MET3A)
- Know the relevant blood tests to determine cause of jaundice (MET3A)
- Understand the role of ultrasound in a patient with obstructive jaundice (MET3A)
- Understand the role of ERCP in a patient with obstructive jaundice (MET3A)
- Understand the role of Surgery in a patient with obstructive jaundice (MET3A)
- Bowel Obstruction (General)
- Be able to institute a management plan for a patient with acute bowel obstruction
- Competently be able to take an accurate and comprehensive history for an acute patient with bowel obstruction
- Competently be able to perform an examination of an acute patient with bowel obstruction
- Be able to present clinical findings in a clear and logical manner
- Be able to differentiate between a mechanical and dynamic obstruction
- Know the difference between simple, complicated obstruction, acute, sub-acute and chronic obstruction
- Be able to write up an intravenous fluid regimen for a patient with bowel obstruction
- Understand the difference between simple and strangulating intestinal obstruction (MET3A)
- Understand the term closed loop obstruction
- Know the differential diagnosis for bowel obstruction
- Be able to differentiate between small and large bowel on abdominal X-Ray and CT
- Small Bowel Obstruction
- Competently be able to examine a patient with small bowel obstruction (MET3A)
- Be able to obtain an accurate history from a patient with an small bowel obstruction (MET3A)
- Know the clinical features of small bowel obstruction (MET3A)
- Know the cardinal signs of small bowel obstruction (MET3A)
- List a differential diagnosis for small bowel obstruction (MET3A)
- Know the causes and classification of small bowel obstruction
- Know the most common causes of mechanical small bowel obstruction (MET3A)
- Understand the biochemical derangements resulting from small bowel obstruction (MET3A)
- Know the complications that can result from small bowel obstruction including: ischaemia, perforation and biochemical derangement (MET3A)
- Know the appropriate imaging in the investigation of acute abdominal pain including: plain radiography (erect chest X-Ray and abdominal X-Ray), abdominal ultrasound scan, CT scan, contrast studies (MET3A)
- Be able to interpret plain abdominal X-Rays showing small bowel obstruction (MET3A)
- Know the conservative treatment of small bowel obstruction (MET3A)
- Understand the importance of small bowel obstruction as an acute surgical presentation. (MET3A)
- Know the indications for surgical intervention and the consequences of resection of small bowel (MET3A)
- Know the operative procedures available for small bowel obstruction (MET3A)
- Know the possible post-op complications of surgical treatment for small bowel obstruction (MET3A)
- Large Bowel Obstruction
- Know the most common causes and classification of mechanical large bowel obstruction (MET3A)
- Understand the biochemical derangements resulting from large bowel obstruction (MET3A)
- Know the clinical features and cardinal signs associated with large bowel obstruction (MET3A)
- Competently be able to obtain an accurate history from a patient with large bowel obstruction (MET3A)
- Know the imaging modalities available to interpret cause of large bowel obstruction (MET3A)
- Be able to interpret plain abdominal X-Rays showing large bowel obstruction (MET3A)
- Know the complications that can result from large bowel obstruction: (ischaemia, perforation and biochemical derangement) (MET3A)
- Understand the importance of large bowel obstruction as an acute surgical presentation (MET3A)
- Know the indications for surgical intervention and the consequences of resection of the large bowel (MET3A)
- Understand the operative procedures available for large bowel obstruction (MET3A)
- Know the possible post-operative complications of surgical treatment (MET3A)
- Obstructive Jaundice
- Trauma to the GI System
- General Outcomes for GI Trauma
- Be able to describe the physiological response to injury
- Be able to describe the principles of surgical treatment to the multi-injured patient
- Know that the severely injured patient requires a high level of physiological support but also appropriately timed surgical intervention
- Understand the concept of damage limitation surgery
- Know the importance of an overall team co-ordinator in the management of trauma.
- Know the importance of precise and accurate documentation and legal considerations
- Know the importance of re-assessment of the patient with regard to earlier interventions
- Know the meaning and significance of a patient with polytrauma
- Know the meaning of missed injuries and be able to list these
- Know the meaning of primary and secondary survey
- Know the meaning and importance of triage
- Know the scale of trauma in the UK
- Recognise the importance of analgesia in the management of trauma patients
- Understand the different mechanisms of trauma injury eg blunt v. penetrating / crush v. blast
- Understand the importance of a continuum of care for the injured patient by a multi-disciplinary team in which responsibility is actively shared
- Understand the importance of the ATLS strategy and systematic approach: rapid primary survey; concurrent resuscitation; secondary survey; continued re-evaluation and monitoring; investigation and definitive care
- Understand the role of investigation and treatment is dependent on the haemodynamic status of the patient
- Abdominal Trauma
- Know how to assess priorities during all phases of management of abdominal trauma
- Know the importance of classifying abdominal trauma into penetrating and blunt injuries
- Know the indication for diagnostic peritoneal lavage in the management of abdominal trauma
- Know the indications for operative and non-operative management of a patient with abdominal trauma
- Know the management of a patient with bowel, liver or splenic injury
- Know the role of computerised tomography (CT) scanning in the management of abdominal trauma
- Know the role of laparoscopy in the management of abdominal trauma
- Know the role of focussed abdominal ultrasound in the management of abdominal trauma
- Know the role of interventional radiology
- Understand abdominal compartment syndrome
- Understand the role of damage control surgery and its indications
- General Outcomes for GI Trauma
- Aneurysms
- Gastrointestinal Cancer
- General Outcomes for Gastrointestinal Cancer
- Oesophageal Cancer
- Gastric Cancer
- Liver Cancer
- Colorectal Cancer
- Understand the incidence and prevalence of colorectal cancer (MET3A)
- Know the risk factors for colorectal cancer (MET3A)
- Know the genetic groups at risk of colorectal cancer (MET3A)
- Be able to take a history for a patient with colorectal disease (MET3A)
- Be able to perform a examination for a patient with colorectal cancer (MET3A)
- Be able to present clinical findings in a clear and logical manner (MET3A)
- Know the symptoms and signs of colorectal cancer (MET3A)
- To understand the investigations for colorectal cancer (MET3A)
- Be able to define the triple assessment for colorectal cancer (MET3A)
- Be aware of the importance of multi disciplinary teams in the management of colorectal cancer (MET3A)
- Know the surgical treatment of colorectal cancer (MET3A)
- Understand the role of the colorectal nurse specialist / colorectal stoma nurse (MET3A)
- Be able to recognise a stoma and its problems (MET3A)
- Understand the role of palliative care in the management of colorectal cancer (MET3A)
- Diarrhoeal and Inflammatory Disorders
- General Outcomes for Diarrhoeal and Inflammatory Disorders
- Be able to take a history of a patient with diarrhoea (MET3A)
- Understand the assessment of a patient with diarrhoea (MET3A)
- Be able to request the investigations to establish a diagnosis (MET3A)
- Be able to offer a differential diagnosis for a patient presenting with diarrhoea (MET3A)
- Be able to understand the different methods of presentation of infectious diarrhoea and inflammatory bowel disease (MET3A)
- Know the treatment options for diarrhoea (MET3A)
- Compare and contrast the clinical and pathological features of the idiopathic types of Ulcerative Colitis and Crohn's Disease (MET3A)
- Describe the clinical features of Crohn's Disease and Ulcerative Colitis; know the main features of other common types of IBD (MET3A)
- Abdominal infections and diarrhoea: prophylaxis and treatment of abdominal sepsis; management of infective diarrhoea (rehydration, isolation, notification, antimicrobials), clostridium difficile (CSP3)
- Understand the public health implications and management of infectious diarrhoea (MET3A)
- Be able to distinguish between the following terms and conditions: increased bowel frequency; diarrhoea; inflammatory / secretory / osmotic diarrhoea; irritable bowel syndrome; diverticular disease; vomiting centre; chemoreceptor trigger zone (MET3A)
- Describe the management of acute infective diarrhoea (MET3A)
- Describe the pathophysiological mechanisms that may produce diarrhoea (MET3A)
- Outline the management of a patient with Crohn's Disease affecting the small bowel (MET3A)
- List the causes of diarrhoea and outline the diagnostic features in the history (MET3A)
- Be able to distinguish between the following terms and conditions: Crohn's Disease; Ulcerative Colitis; Irritable Bowel Syndrome; Acute Flare; Toxic Megacolon; Infective Diarrhoea (MET3A)
- Be able to recognise when surgical referral is appropriate (MET3A)
- Know how manifestations of Crohn's depends on site and severity of disease (MET3A)
- Know how to manage a patient with active Crohn's Disease in line with current BSG guidelines (MET3A)
- Know how to manage a patient with severe ulcerative colitis in line with current BSG guidelines (MET3A)
- Understand the role of monitoring patients with inflammatory bowel disease (MET3A)
- Inflammatory Bowel Disease
- Understand from a patient perspective of living with inflammatory disease (MET3A)
- Understand the difference between Crohns Disease and Ulcerative Colitis (MET3A)
- Be aware of the specialist drugs: Thiopurines eg Azathipprine; Ciclosporin; Methotrexate; Anti-TNFa eg infliximab (MET3A)
- Appreciate the mutidisciplinary team approach to the treatment of IBD (MET3A)
- Recognise when a patient should be referred for specialist treatment (MET3A)
- Understand the medical options of treatment of IBD (MET3A)
- Use specialist drugs under close specialist supervision only and monitor patients taking these drugs (MET3A)
- Understand the surgical options of treatment of IBD (MET3A)
- Recognise that patients presenting to you unwell, may be so as a result of an adverse reaction these medications; be aware of important adverse effects and interactions to avoid in inadvertent serious drug-drug interactions (MET3A)
- Understand the following issues with a patient who has an inflammatory bowel disease: importance of nutrition; drugs used to maintain remission; surveillance for colonic cancer; risk of osteoporosis and measures to reduce this; sources of support and info (MET3A)
- List the complications of IBD, in particular the extra-intestinal manifestations (MET3A)
- Outline the investigation of a patient suspected of having inflammatory bowel disease (MET3A)
- Outline the management of a patient with acute ulcerative colitis (MET3A)
- Outline the risk of colonic malignancy in IBD; describe the methods used in screening for malignancy in IBD (MET3A)
- Be able to take a history from, and examine a patient with inflammatory bowel disease (MET3A)
- Be able to implement a strategy for pain control in a patient with inflammatory bowel disease (MET3A)
- Be able to recognise potentially life-threatening complications of inflammatory bowel disease (MET3A)
- General Outcomes for Diarrhoeal and Inflammatory Disorders
- Vascular Conditions
- GI Surgery and Anaesthetics (General)
- Surgery - General
- Be able to describe the complications from major abdominal surgery (MET3A)
- Be able to describe the indications, operations and complications associated with oesophagectomy and gastrectomy (MET3A)
- Know the indications, operations and complications associated with laparoscopic cholecystecomy (MET3A)
- Know the indications, operations and complications associated with right hemicolectomy, anterior resection and the formation of stoma (MET3A)
- Be able to describe the indications, operations and complications associated with Hartman's Operation and abdominoperineal excision of the rectum (MET3A)
- Be able to describe the indications, operations and complications associated with splenectomy (MET3A)
- Be able to describe the indications, operations and complications associated with treatment for haemorrhoids, fissures and fistula (MET3A)
- Anaesthetics - General
- Pre-Operative Assessment
- Anaesthetics - Post-operative Complications
- Surgery - General
- Malabsorption Disorders